mriselMagnetic Resonance in SolidsMagnetic Resonance in Solids2072-5981Kazan Federal Universitymrisel-197Research ArticleСтатьиInhibition of Water Transport Across Cell Membranes by DimephosphonSundukovaM. V.

Kremlevskaya, 18, Kazan 420008

maya_sun@mail.ruMutinaA. R.

Kremlevskaya, 18, Kazan 420008

SkorinkinA. I.

Kremlevskaya, 18, Kazan 420008

Kazan State UniversityRussian Federation2006200120248169Copyright © Sundukova M.V., Mutina A.R., Skorinkin A.I., 20242024Sundukova M.V., Mutina A.R., Skorinkin A.I.Sundukova M.V., Mutina A.R., Skorinkin A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mrsej.ru/jour/article/view/197

The inhibitory effect of widely used drug dimephosphon on water transport in human red cells at 37?C was studied in comparison to intact human erythrocytes. Intracellular water residence time characterizing water permeability of cell membrane was obtained with doping NMR technique. Inhibitory effect of dimephosphon is concentration-dependent.

water permeabilityred blood cell membraneNMRdrug-membrane interactionThe work was supported by RFBR projects № 04-03-32861, № 06-04-48160 and RNP 2.1.1.3222.ReferencesPryazhnikov E., Skorinkin A., Garaev R., Giniatullin R., Vizel A., Shchukina L. Bull Exp Biol Med. 139, 437 (2005).Pryazhnikov E., Skorinkin A., Garaev R., Giniatullin R., Vizel A., Shchukina L. Bull Exp Biol Med. 139, 437 (2005).Herbst M., Goldstein J. Am. J. Physiol. - Cell Physiology 256, 1097 (1989).Herbst M., Goldstein J. Am. J. Physiol. - Cell Physiology 256, 1097 (1989).Benga G., Popescu O., Borza V., Pop V., Hodarnau A. J. Membr. Biol. 108, 105 (1989).Benga G., Popescu O., Borza V., Pop V., Hodarnau A. J. Membr. Biol. 108, 105 (1989).

The authors declare that there are no conflicts of interest present.