mriselMagnetic Resonance in SolidsMagnetic Resonance in Solids2072-5981Kazan Federal Universitymrisel-171Research ArticleСтатьиObtaining spatial structure of cyclosporine (CsA) in chloroform using 2D NMRManinA. Y.

Kremlevskaya, 18, Kazan 420008

anton.manin@live.ksu.ruEfimovS. V.

Kremlevskaya, 18, Kazan 420008

KlochkovV. V.

Kremlevskaya, 18, Kazan 420008

Kazan Federal UniversityRussian Federation2011200120241322126Copyright © Manin A.Y., Efimov S.V., Klochkov V.V., 20242024Manin A.Y., Efimov S.V., Klochkov V.V.Manin A.Y., Efimov S.V., Klochkov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mrsej.ru/jour/article/view/171

In this work the cyclic peptide cyclosporine was investigated. Signal assignment was made according to 2D NMR spectra. Using NOESY spectra and computer simulation the spatial structure was also obtained.

high-resolution NMRstructure determination by NMRspectroscopic techniques in biophysics and medical physicsReferencesHsu V.L., Heald S.L., Harding M.W., Handschumacher R.E., Armitage I.M. Biochem. Pharm. 40, 131 (1990)Hsu V.L., Heald S.L., Harding M.W., Handschumacher R.E., Armitage I.M. Biochem. Pharm. 40, 131 (1990)Weber C., Wider G., Freyberg B., Traber R., Braun W., Widmer H., Wuthrich K. Biochemistry 30, 6563 (1991)Weber C., Wider G., Freyberg B., Traber R., Braun W., Widmer H., Wuthrich K. Biochemistry 30, 6563 (1991)Fesik S.W., Gampe R.T., Eaton H.L., Gemmecker G., Olejniczak E.T., Neri P., Holzman T.F., Egan D.A., Edalji R., Simmer R., Helfrich R., Hochlowski J., Jackson M. Biochemistry 30, 6574 (1991)Fesik S.W., Gampe R.T., Eaton H.L., Gemmecker G., Olejniczak E.T., Neri P., Holzman T.F., Egan D.A., Edalji R., Simmer R., Helfrich R., Hochlowski J., Jackson M. Biochemistry 30, 6574 (1991)Yingqing R., Luwei Z., Qing X., Yalkowsky S.H. AAPS PharmSciTech 2, 23 (2001)Yingqing R., Luwei Z., Qing X., Yalkowsky S.H. AAPS PharmSciTech 2, 23 (2001)Delaglio F., Grzesiek S., Vuister G., Zhu G., Pfeifer J., Bax A. J. Biomol. NMR 6, 277 (1995)Delaglio F., Grzesiek S., Vuister G., Zhu G., Pfeifer J., Bax A. J. Biomol. NMR 6, 277 (1995)

The authors declare that there are no conflicts of interest present.