mriselMagnetic Resonance in SolidsMagnetic Resonance in Solids2072-5981Kazan Federal Universitymrisel-168Research ArticleСтатьиNMR study of cholesterol complexes with glycyrrhizic acidGluschenkoO. Yu.

Institutskaya str., 3, Novosibirsk 630090

olga.gluschenko@gmail.comPolyakovN. E.

Institutskaya str., 3, Novosibirsk 630090

LeshinaT. V.

Institutskaya str., 3, Novosibirsk 630090

Institute of Chemical Kinetics and CombustionRussian Federation20112001202413259Copyright © Gluschenko O.Y., Polyakov N.E., Leshina T.V., 20242024Gluschenko O.Y., Polyakov N.E., Leshina T.V.Gluschenko O.Y., Polyakov N.E., Leshina T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mrsej.ru/jour/article/view/168

Nuclear magnetic resonance (NMR) relaxation technique was applied to study the interaction of cholesterol with natural complexant - glycyrrhizic acid. Stoichiometry, stability constants and thermodynamic parameters of the complex have been measured. We propose that the complexation with glycyrrhizic acid could be an effective approach to regulate the cholesterol level inside and outside of cage membranes.

NMRrelaxationcholesterolglycyrrhizic acidatherosclerosiscomplex of cholesterolThis work was supported by the Priority Program for Basic Research RAS. Project No 4: “Study of supramolecular complexes of plant metabolites and their derivatives with hypocholesterolemic agents by physicochemical methods”, 2009-2011.ReferencesLeonarduzzi G., Sottero B., Galli G. The Journal of Nutritional Biochemistry 13, 700 (2002)Leonarduzzi G., Sottero B., Galli G. The Journal of Nutritional Biochemistry 13, 700 (2002)Ostlund R., Racette S., Stenson W. Nutr. Rev. 60, 349 (2002)Ostlund R., Racette S., Stenson W. Nutr. Rev. 60, 349 (2002)Usui K., Hulleman J.D., Paulsson J.F., Siegel S.J., Powers E.T., Kelly J.W. Proceedings of the National Academy of Sciences 106, 44 (2009)Usui K., Hulleman J.D., Paulsson J.F., Siegel S.J., Powers E.T., Kelly J.W. Proceedings of the National Academy of Sciences 106, 44 (2009)Wentworth P., Nieva J., Takeuchi C., Galve R., Wenthworth A., Dilley R., DeLaria G., Saven A., Babior B., Janda K., Eschenmoser A., Lerner R. Science 302, 1053 (2003)Wentworth P., Nieva J., Takeuchi C., Galve R., Wenthworth A., Dilley R., DeLaria G., Saven A., Babior B., Janda K., Eschenmoser A., Lerner R. Science 302, 1053 (2003)Alcalde M.A., Antelo A., Jover A., Meijide F., Tato J.V. Journal of Inclusion Phenomena and Macrocyclic Chemistry 63, 309 (2009)Alcalde M.A., Antelo A., Jover A., Meijide F., Tato J.V. Journal of Inclusion Phenomena and Macrocyclic Chemistry 63, 309 (2009)Kilsdonk E.P.C., Yancey P.G., Stoudt G.W., Bangerter F.W, Johnson W.J., Phillips M.C., Rothblat G.H. The Journal of Biological Chemistry 270, 17250 (1995)Kilsdonk E.P.C., Yancey P.G., Stoudt G.W., Bangerter F.W, Johnson W.J., Phillips M.C., Rothblat G.H. The Journal of Biological Chemistry 270, 17250 (1995)Fiore C., Eisenhut M., Krausse R., Ragazzi E., Pellati D., Armanint D., Bielenberg J. Phytotherapy Research 22, 141 (2008)Fiore C., Eisenhut M., Krausse R., Ragazzi E., Pellati D., Armanint D., Bielenberg J. Phytotherapy Research 22, 141 (2008)Tolstikov G.A., Baltina L.A., Shults E.E., Pokrovskii A.G. Russ. J. Bioorg. Chem. 23, 625 (1997)Tolstikov G.A., Baltina L.A., Shults E.E., Pokrovskii A.G. Russ. J. Bioorg. Chem. 23, 625 (1997)Fuhrman B., Buch S., Vaya J., Belinky P., Coleman R., Hayek T., Aviram M. The American Journal of Clinical Nutrition 66, 267 (1997)Fuhrman B., Buch S., Vaya J., Belinky P., Coleman R., Hayek T., Aviram M. The American Journal of Clinical Nutrition 66, 267 (1997)Polyakov N.E., Khan V.K., Taraban M.B., Leshina T.V. J. Phys. Chem. B 112, 4435 (2008).Polyakov N.E., Khan V.K., Taraban M.B., Leshina T.V. J. Phys. Chem. B 112, 4435 (2008).Polyakov N.E., Leshina T.V., Salakhutdinov N.F., Kispert L.D. J. Phys. Chem. B 110, 6991 (2006)Polyakov N.E., Leshina T.V., Salakhutdinov N.F., Kispert L.D. J. Phys. Chem. B 110, 6991 (2006)Kornievskaya V.S., Kruppa A.I., Polyakov N.E., Leshina T.V., J. Incl. Phenom. Macrocycl. Chem. 60, 123 (2007)Kornievskaya V.S., Kruppa A.I., Polyakov N.E., Leshina T.V., J. Incl. Phenom. Macrocycl. Chem. 60, 123 (2007)

The authors declare that there are no conflicts of interest present.